Slow-Release RGD-Peptide Hydrogel Monoliths
نویسندگان
چکیده
منابع مشابه
Slow-release RGD-peptide hydrogel monoliths.
We report on the formation of hydrogel monoliths formed by functionalized peptide Fmoc-RGD (Fmoc: fluorenylmethoxycarbonyl) containing the RGD cell adhesion tripeptide motif. The monolith is stable in water for nearly 40 days. The gel monoliths present a rigid porous structure consisting of a network of peptide fibers. The RGD-decorated peptide fibers have a β-sheet secondary structure. We prov...
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Background RGD-containing peptides are able to prevent binding of ligands to certain integrins such as a!IIb3 (glycoprotein Ilb/llla) and C4a33 and as such are inhibitors for platelet aggregation and smooth muscle cell migration, both of which are involved in neointima formation. Methods and Results Hamster carotid arteries were damaged, and neointima formation was determined at different time ...
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ژورنال
عنوان ژورنال: Langmuir
سال: 2012
ISSN: 0743-7463,1520-5827
DOI: 10.1021/la302071e